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KMID : 0356919920250040684
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Korean Journal of Anesthesiology
1992 Volume.25 No. 4 p.684 ~ p.693
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Clinical Studies on Propofol(Diprivan)
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Abstract
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Twenty one patients undergoing elective orthopedic or gynecologic operations were randomly assigned to receive anesthesia with propofol 2.0mg-propofol infusion 6~10mg/kg/hr-nitrous oxide 50%(propofol group) or thiopental
4~5mg/kg-isoflurane-nitrous
oxdie 50%(Thiopental group). The cardiovascular effects effects were initial decreases of systolic, diastolic, mean arterial pressure, cardiac output and stroke volume and increase in heart rates. There was no difference between group. After
tracheal
intubation systolic, diastolic and mean arterial pressure increased in propofol group but not in isoflurane group. During maintenance there was no difference in hemodynamic parameters between groups. Hematologic, renal and hepatic functions
revealed no
difference between pre-and post-anesthesia in both groups. The cortisol levels were not changed after anesthesia in both groups. The recovery time was significantly shorter in porpofol group than in isoflurane group.
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